Relationship between obstructive sleep apnea cardiac complications and sleepiness in children with Down syndrome

• Published in: Sleep medicine Vol. 17; pp. 18 - 24
• Main Authors: Konstantinopoulou, Sofia, Tapia, Ignacio E, Kim, Ji Young, Xanthopoulos, Melissa S, Radcliffe, Jerilynn, Cohen, Meryl S, Hanna, Brian D, Pipan, Mary, Cielo, Christopher, Thomas, Allison J, Zemel, Babette, Amin, Raouf, Bradford, Ruth, Traylor, Joel, Shults, Justine, Marcus, Carole L
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2016
• Subjects: Adolescent; Cardiovascular Diseases - etiology; Child; Continuous Positive Airway Pressure; Down syndrome; Down Syndrome - complications; Female; Humans; Male; Neurology; Noninvasive ventilation; Polysomnography; Sleep Apnea, Obstructive - complications; Sleep Apnea, Obstructive - physiopathology; Sleep Apnea, Obstructive - therapy; Sleep Medicine; Sleep Wake Disorders - etiology; Sleep-disordered breathing; Young Adult; AASM; TST; American Academy of Sleep Medicine; Noninvasive ventilation; Down syndrome; IQR; interquartile range; total sleep time; Sleep-disordered breathing; EMG; electromyogram
• ISSN: 1389-9457; 1878-5506
• DOI: 10.1016/j.sleep.2015.09.014

Highlights • Children with Down syndrome underwent polysomnography and echocardiography. • Those with obstructive sleep apnea (OSA) were randomized to actual or sham continuous positive airway pressure (CPAP). • Subjects had a high rate of OSA, despite previous adenotonsillectomy. • There was a low rate of pulmonary hypertension. • Diastolic dysfunction correlated with OSA severity and improved with CPAP.