XIAP, the guardian angel

Controlling the activity of caspases is essential for the appropriate execution of cell death and the regulation of cell survival. One cellular inhibitor of apoptosis, XIAP, has emerged as a crucial regulator of caspases, and is itself subject to complex negative regulation.

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Bibliographic Details
Published inNature reviews. Molecular cell biology Vol. 2; no. 7; pp. 550 - 556
Main Authors Holcik, Martin, Korneluk, Robert G.
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.07.2001
Nature Publishing Group
Subjects
Animals
Apoptosis
Biochemistry
Biomedical and Life Sciences
Cancer Research
Caspases - chemistry
Caspases - metabolism
Cell Biology
Developmental Biology
Enzyme Inhibitors - metabolism
Humans
Life Sciences
Models, Biological
Models, Molecular
opinion-2
Proteins - genetics
Proteins - metabolism
Signal Transduction
Stem Cells
X-Linked Inhibitor of Apoptosis Protein
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Summary:Controlling the activity of caspases is essential for the appropriate execution of cell death and the regulation of cell survival. One cellular inhibitor of apoptosis, XIAP, has emerged as a crucial regulator of caspases, and is itself subject to complex negative regulation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1471-0072
1471-0080
DOI:10.1038/35080103