Medicinal metabolites with common biosynthetic pathways in Solanum nigrum

• Published in: Plant biotechnology reports Vol. 13; no. 4; pp. 315 - 327
• Main Authors: Jabamalairaj, Anitha, Priatama, Ryza A., Heo, Jung, Park, Soon Ju
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.08.2019; Springer Nature B.V; 한국식물생명공학회
• Subjects: Agriculture; alpha-chaconine; Anticancer properties; Antioxidants; Aquatic life; beta-sitosterol; Biomedical and Life Sciences; biosynthesis; Biotechnology; Cell Biology; CRISPR; CRISPR-Cas systems; Diabetes mellitus; Glycoalkaloids; Herbal medicine; Life Sciences; Medicinal plants; Metabolites; plant architecture; Plant Biochemistry; Plant Sciences; Review; scopoletin; Secondary metabolites; solanine; Solanum nigrum; Therapeutic applications; therapeutics; toxicity; 농학; Medicinal plants; Therapeutic properties; Molecular breeding; Secondary metabolites
• ISSN: 1863-5466; 1863-5474
• DOI: 10.1007/s11816-019-00549-w

Solanum nigrum is a medicinal plant belonging to the Solanaceae family. It possesses various therapeutic properties such as anticancer, antioxidant, hepatoprotective, antiulcer, antiinflammatory, antihyperlipidemic, antidiabetic, antibacterial, and antiseizure properties. Numerous secondary metabolites have been isolated from S. nigrum, including (+) syringaresinol (II), (+)-medioresinol (III), scopoletin (IV), tetracosanoic acid (V), and beta-sitosterol (IV). They also contain a variety of toxic secondary metabolites such as alpha-Solanine and alpha-Chaconine, which are steroidal glycoalkaloids. Here, we showed the potential of CRISPR/Cas9 technology to improve and enhance the plant architecture, secondary metabolites, and therapeutic applications in eliminating toxic compounds, especially solanine and chaconine, in S. nigrum .