Biomarker study of the biological parameter and neurotransmitter levels in autistics

• Published in: Molecular and cellular biochemistry Vol. 474; no. 1-2; pp. 277 - 284
• Main Authors: Meyyazhagan, Arun, Balasubramanian, Balamuralikrishnan, Easwaran, Murugesh, Alagamuthu, Karthick Kumar, Shanmugam, Sureshkumar, Kuchi Bhotla, Haripriya, Pappusamy, Manikantan, Arumugam, Vijaya Anand, Thangaraj, Arulprakash, Kaul, Tanushri, Keshavarao, Sasikala, Cacabelos, Ramon
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2020; Springer
• Subjects: Antioxidants; Antioxidants - analysis; Autism; Autistic Disorder - blood; Autistic Disorder - pathology; Biochemistry; Biomarkers - blood; Biomedical and Life Sciences; Cardiology; Case-Control Studies; Child; Comparative analysis; Ethylenediaminetetraacetic acid; Female; Hexokinase - blood; Humans; Life Sciences; Male; Medical Biochemistry; Neurotransmitter Agents - blood; Oncology; Oxidative Stress; Pyruvate Kinase - blood; Autism; Oxidative stress; Biochemical; Neurotransmitters; Antioxidant proteins
• ISSN: 0300-8177; 1573-4919
• DOI: 10.1007/s11010-020-03851-2

Autism is a prevalent developmental disorder that combines repetitive behaviours, social deficits and language abnormalities. The present study aims to assess the autistic subjects using DSM IV-TR criteria followed with the analysis of neurotransmitters, biochemical parameters, oxidative stress and its ions in two groups of autistic subjects (group I < 12 years; group II ≥ 12 years). Antioxidants show a variation of 10% increase in controls compared to autistic age < 12 years. The concentration of pyruvate kinase and hexokinase is elevated in controls approximately 60% and 45%, respectively, with the significance of 95 and 99%. Autistic subjects showed marked variation in levels of neurotransmitters, oxidative stress and its related ions. Cumulative assessment of parameters related to biochemical markers and neurotransmitters paves the way for autism-based research, although these observations draw interest in an integrated approach for autism.