A note on the effect of within‐strain sample sizes on QTL mapping in recombinant inbred strain studies

This note explores the effect of within‐strain sample sizes on the correlations between a phenotype and a molecular‐genetic marker in a battery of inbred strains. It is shown that the maximum correlation possible between a molecular marker and a behavioral or neuronal phenotype equals the additive‐g...

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Bibliographic Details
Published inGenes, brain and behavior Vol. 3; no. 4; pp. 249 - 251
Main Author Crusio, W. E.
Format Journal Article
LanguageEnglish
Published Oxford, UK; Malden, USA Munksgaard International Publishers 01.08.2004
Subjects
Animals
Animals, Inbred Strains - genetics
Chromosome Mapping - statistics & numerical data
Environmental variance
genetic correlation
Genetic Markers
Models, Genetic
quantitative genetics
Quantitative Trait Loci - genetics
Quantitative Trait, Heritable
Recombination, Genetic
Sample Size
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Summary:This note explores the effect of within‐strain sample sizes on the correlations between a phenotype and a molecular‐genetic marker in a battery of inbred strains. It is shown that the maximum correlation possible between a molecular marker and a behavioral or neuronal phenotype equals the additive‐genetic correlation. How close the strain correlation will approach the additive‐genetic correlation depends only on heritability and within‐strain sample sizes. The equations derived can be used to optimize designs of studies attempting to localize Quantitative Trait Loci utilizing Recombinant Inbred Strains, provided information about the heritability of the character under study is available.
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ISSN:1601-1848
1601-183X
DOI:10.1111/j.1601-183X.2004.00079.x