Susd2/SUSD2, a putative tumor suppressor gene, inhibits growth of colorectal cancer cells

We constructed inducible expression system of Susd2 gene which we previously identified as a novel tumor suppressor gene. Here we report the growth inhibition of colorectal cancer HCT116 cells and fibrosarcoma HT1080 cells by inducible expression of Susd2 protein from HCT/G5Susd2 and HT/G5Susd2 cell...

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Bibliographic Details
Published inAnnals of Cancer Research and Therapy Vol. 26; no. 2; pp. 77 - 81
Main Authors Andoh, Toshiwo, Kumamoto, Kensuke, Suzuki, Shinichi, Matsumoto, Yoshiko, Oukouchi, Chiyo, Iwadate, Manabu, Suzuki, Satoshi, Mizunuma, Hiroshi, Takenoshita, Seiichi
Format Journal Article
LanguageEnglish
Published Tokyo The Japanese Society of Strategies for Cancer Research and Therapy 21.08.2018
Japan Science and Technology Agency
Subjects
Cancer
Colorectal cancer
Colorectal carcinoma
Fibrosarcoma
Susd2/SUSD2
Tumor suppressor gene
Tumor suppressor genes
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Summary:We constructed inducible expression system of Susd2 gene which we previously identified as a novel tumor suppressor gene. Here we report the growth inhibition of colorectal cancer HCT116 cells and fibrosarcoma HT1080 cells by inducible expression of Susd2 protein from HCT/G5Susd2 and HT/G5Susd2 cells by infection of Ad/G4VP2, as revealed by colony formation and growth behavior. Thus, we found that Susd2 inhibits growth of cancer cells and this information may benefit to patients with malignant diseases.
ISSN:1344-6835
1880-5469
DOI:10.4993/acrt.26.77