Undifferentiated carcinoma of the gallbladder. A clinicopathologic, histochemical, and immunohistochemical study of 21 patients with a poor prognosis

Among 284 cases of carcinoma of the gallbladder, 21 were identified as undifferentiated carcinoma (UC), with little glandular or other specific epithelial differentiation. These tumors were classified into three histologic types according to the components: (1) small cell type (eight cases); (2) ple...

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Published inCancer Vol. 61; no. 9; pp. 1872 - 1879
Main Authors Guo, Ke‐Jian, Yamaguchi, Koji, Enjoji, Munetomo
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.05.1988
Wiley-Liss
Subjects
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - analysis
Carcinoma - analysis
Carcinoma - classification
Carcinoma - pathology
Female
Gallbladder Neoplasms - analysis
Gallbladder Neoplasms - pathology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Immunoenzyme Techniques
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Prognosis
Staining and Labeling
Tumors
Human
Immunohistochemistry
Pathology
Prognosis
Digestive diseases
Tumor
Gallbladder
Histochemistry
Undifferentiated tumor
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Summary:Among 284 cases of carcinoma of the gallbladder, 21 were identified as undifferentiated carcinoma (UC), with little glandular or other specific epithelial differentiation. These tumors were classified into three histologic types according to the components: (1) small cell type (eight cases); (2) pleomorphic cell type (eight cases); and (3) spindle cell or pseudosarcomatous type (five cases). Histochemical and immunohistochemical study by the immunoperoxidase technique revealed that most of the tumors (13/21) contained mucosubstances, and that all examples of the UC were immunoreactive for epithelial membrane antigen (EMA), keratin, and carcinoembryonic antigen (CEA), thereby indicating the epithelial nature of the neoplastic cells. Vimentin immunoreactivity was found in nine tumors. In 19, the tumor contained various neoplastic endocrine cells, including somatostatin‐immunoreactive (14/19), gastrinimmunoreactive (14/19), human chorionic gonadotropin (HCG)‐immunoreactive (9/19), pancreatic polypeptide‐immunoreactive (4/19), and serotonin‐immunoreactive cells (4/19). The prognosis of patients with UC of the gallbladder was poorer than that of patients with differentiated adenocarcinoma.
Bibliography:Fellows in the Department of Surgery I, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19880501)61:9<1872::AID-CNCR2820610925>3.0.CO;2-Q