Fluorescent Properties of the Amidinophenylporphyrins Interacting with DNA

5,10,15,20-Tetrakis（4-amidinolphenyl）porphyrin, its Zn complex and amidinolphenyl bispophyrin interacting with calf thymus DNA were investigated by fluorescence emission spectra and fluorescence life time measurements were also shown. The binding modes of these compounds were recorded and lifetimes...

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Bibliographic Details
Published inChinese journal of chemistry Vol. 30; no. 3; pp. 529 - 533
Main Author 王凯 李天 喻发全 郑云满 黄伟国 邝维正 李早英
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.03.2012
WILEY‐VCH Verlag
Wiley
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Subjects
amidinophenylporphyrin
binding mode
Chemistry
Chemistry, Multidisciplinary
Deoxyribonucleic acid
DNA
Emission measurements
Fluorescence
lifetime
Physical Sciences
Science & Technology
化合物
卟啉
小牛胸腺DNA
治疗药物
相互作用
荧光光谱
荧光寿命测量
荧光性质
binding mode
SPECTROSCOPY
fluorescence
PHOTOCLEAVAGE
DNA
PHOTOSENSITIZER
lifetime
amidinophenylporphyrin
CATIONIC PORPHYRIN
BINDING
Online AccessGet full text
ISSN1001-604X
1614-7065
DOI10.1002/cjoc.201100564

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Summary:5,10,15,20-Tetrakis（4-amidinolphenyl）porphyrin, its Zn complex and amidinolphenyl bispophyrin interacting with calf thymus DNA were investigated by fluorescence emission spectra and fluorescence life time measurements were also shown. The binding modes of these compounds were recorded and lifetimes of luminescence were meas- ured as a function of the nature to understand the interaction with DNA. The results suggest those amidinopor-phyrins are promising new photodynamic therapeutic agents.
Bibliography:5,10,15,20-Tetrakis（4-amidinolphenyl）porphyrin, its Zn complex and amidinolphenyl bispophyrin interacting with calf thymus DNA were investigated by fluorescence emission spectra and fluorescence life time measurements were also shown. The binding modes of these compounds were recorded and lifetimes of luminescence were meas- ured as a function of the nature to understand the interaction with DNA. The results suggest those amidinopor-phyrins are promising new photodynamic therapeutic agents.
31-1547/O6
amidinophenylporphyrin, binding mode, lifetime, DNA, fluorescence
Wang, Kai Li, Tian Yu, Faquana Zheng, Yunman Wong, Wai-Kwok Kwong, Daniel W. J.C Li, Zaoying a Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan, Hubei 430073, China b College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China c Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
ArticleID:CJOC201100564
istex:086B6236B7B1913B72F31A295A19526F2A3A4718
the National Natural Science Foundation of China - No. 20902071, 20672082
Hong Kong Research Grants Council - No. HKBU 202407
ark:/67375/WNG-D6PW0QMQ-4
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
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ISSN:1001-604X
1614-7065
DOI:10.1002/cjoc.201100564