Malignant rhabdoid tumor of the extremity

Two cases of malignant rhabdoid tumor (MRT) involving the sciatic nerve are described. Despite the close affiliation of the tumor with neural tissue, staining characteristics in these patients do not suggest a neural origin of MRT. Survival in patients with renal and extrarenal MRT has been poor. Ou...

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Bibliographic Details
Published inCancer Vol. 60; no. 5; pp. 1056 - 1059
Main Authors Kent, Angela L., Mahoney, Donald H., Gresik, Mary V., Steuber, Charles P., Fernbach, Donald J.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.09.1987
Wiley-Liss
Subjects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biological and medical sciences
Child, Preschool
Combined Modality Therapy
Diseases of the osteoarticular system
Humans
Male
Medical sciences
Neoplasm Invasiveness
Neoplasms, Muscle Tissue - drug therapy
Neoplasms, Muscle Tissue - surgery
Sciatic Nerve - pathology
Thigh
Tumors of striated muscle and skeleton
Limb
Rhabdomyosarcoma
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Summary:Two cases of malignant rhabdoid tumor (MRT) involving the sciatic nerve are described. Despite the close affiliation of the tumor with neural tissue, staining characteristics in these patients do not suggest a neural origin of MRT. Survival in patients with renal and extrarenal MRT has been poor. Our patients were treated with an aggressive chemotherapy program using cisplatin, Adriamycin (doxorubicin), vincristine, cyclophosphamide, actinomycin D, and DTIC. One child died of progressive disease; the other is well 35 months after diagnosis.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19870901)60:5<1056::AID-CNCR2820600521>3.0.CO;2-Q