A Glucose-Containing Ether Lipid (Glc-PAF) as an Antiproliferative Analogue of the Platelet-Activating Factor

A new group of active substances, to which 1 belongs, inhibit cell proliferation and initiate programmed cell death (apoptosis) in keratinocytes. The glucosylated phospholipid 1 was synthesized from (S)‐isopropylideneglycerol in nine steps with an overall yield of 25 %.

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 37; no. 3; pp. 351 - 353
Main Authors Mickeleit, Michael, Wieder, Thomas, Arnold, Michael, Geilen, Christoph C., Mulzer, Johann, Reutter, Werner
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag GmbH 16.02.1998
WILEY‐VCH Verlag GmbH
Wiley
Subjects
Apoptosis
Chemistry
Chemistry, Multidisciplinary
Glycosides
Phospholipids
Physical Sciences
Platelet-activating factor
Proliferation inhibitors
Science & Technology
PHOSPHATIDYLCHOLINE BIOSYNTHESIS
proliferation inhibitors
INVITRO
apoptosis
platelet-activating factor
CELL-PROLIFERATION
HEXADECYLPHOSPHOCHOLINE
phospholipids
glycosides
Glycosides
Phospholipids
Platelet-activating factor
Proliferation inhibitors
Apoptosis
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Summary:A new group of active substances, to which 1 belongs, inhibit cell proliferation and initiate programmed cell death (apoptosis) in keratinocytes. The glucosylated phospholipid 1 was synthesized from (S)‐isopropylideneglycerol in nine steps with an overall yield of 25 %.
Bibliography:ark:/67375/WNG-3TS94WN5-5
ArticleID:ANIE351
istex:5E8ADCF2254F0C745BD684E66302AD2451B5AED4
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19980216)37:3<351::AID-ANIE351>3.0.CO;2-P