Spontaneous cure of end‐stage acute nonlymphocytic leukemia complicated with chloroma (granulocytic sarcoma)

• Published in: Cancer Vol. 58; no. 5; pp. 1101 - 1105
• Main Authors: Takaue, Yoichi, Culbert, Steven J., Van Eys, Jan, Dalton, Willard T., Cork, Ann, Trujillo, Jose M.
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01.09.1986; Wiley-Liss
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Bone Marrow - pathology; Bone Marrow - ultrastructure; Child; Doxorubicin - therapeutic use; Eye Neoplasms - drug therapy; Eye Neoplasms - pathology; Eye Neoplasms - radiotherapy; Female; Follow-Up Studies; Hematologic and hematopoietic diseases; Humans; Karyotyping; Leukemia - drug therapy; Leukemia - pathology; Leukemia, Myeloid - drug therapy; Leukemia, Myeloid - pathology; Leukemia, Myeloid - radiotherapy; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Medical sciences; Nasal Cavity - pathology; Neoplasm Invasiveness; Neoplasms, Multiple Primary; Paranasal Sinus Neoplasms - drug therapy; Paranasal Sinus Neoplasms - pathology; Paranasal Sinus Neoplasms - radiotherapy; Translocation, Genetic; Human; Recurrence; Cure; Acute; Spontaneous; Cytogenetics; Tumor; Chloroma; Hemopathy; Child; Nonlymphocytic leukemia; Terminal stade
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/1097-0142(19860901)58:5<1101::AID-CNCR2820580520>3.0.CO;2-L

Spontaneous regression of end‐stage acute nonlymphocytic leukemia (ANLL) complicated with chloroma (granulocytic sarcoma) was observed in a child after the patient had been sent home for terminal care. The patient was initially found to have the 8; 21 translocation and has survived without any evidence of disease 101 months after the initial diagnosis and 80 months after the discontinuation of all therapy. Spontaneous regression of a wide variety of tumors has been reported, but this observed case has no features in common with those cases. Special implications of this case are discussed. Cancer 58:1101‐1105, 1986.