Effects of extract of oyster on lipid metabolism in rats

• Published in: Journal of ethnopharmacology Vol. 59; no. 3; pp. 117 - 123
• Main Authors: Kimura, Yoshiyuki, Ohminami, Hiroji, Okuda, Hiromichi
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 1998; Elsevier
• Subjects: Animals; Biological and medical sciences; Dietary Fats, Unsaturated - administration & dosage; Epinephrine - pharmacology; Fat cells; General pharmacology; Hyperlipemia; hyperlipidemia; Hyperlipidemias - therapy; Lipid Metabolism; Lipids - biosynthesis; Lipids - blood; Lipolysis - drug effects; liver; Liver - metabolism; Liver - pathology; liver injury; Male; Medical sciences; Ostrea; ostreas gingas; Ostreidae; Oyster ( Ostrea gingas); Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Rats; Rats, Wistar; Shellfish; Transaminases - blood; Fat cells; Hyperlipemia; Lipid metabolism; Oyster ( Ostrea gingas); Adipocyte; Rat; Ostrea; Lipids; Folk medicine; Bivalvia; Dyslipemia; Lipogenesis; Adenosine; Rodentia; Oral administration; Animal origin; Metabolic diseases; Metabolism; In vitro; Biological activity; Lipolysis; Feeding; In vivo; Vertebrata; Mammalia; Treatment; Animal; Invertebrata; Mollusca; Antilipemic agent
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(97)00115-3

We examined the effects of oyster ( Ostrea gingas Thunb.) water extracts on hyperlipemia and liver injury produced in rats by feeding on peroxidized oil. The extracts of oyster were found to reduce the levels of serum free fatty acid, triglyceride, lipid peroxide and liver cholesterol in the peroxidized oil-treated rats. In addition, we found that the water extracts of oyster inhibited adrenaline-induced lipolysis, and that these extracts stimulated lipogensis from glucose in isolated fat cells of rats. The active substance was isolated and identified as adenosine by direct comparison with an authentic sample.