The complexities of dystroglycan

The notion of dystroglycan as a simple laminin-binding receptor is increasingly being challenged. New roles and new binding partners are continually emerging. Recent structural advances have provided exciting new insights into the precise molecular interactions between dystroglycan and other key com...

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Bibliographic Details
Published inTrends in Biochemical Sciences Vol. 26; no. 2; pp. 118 - 124
Main Author Winder, Steven J
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2001
Subjects
Animals
Cell Adhesion
Cell Division
Cytoskeletal Proteins - chemistry
Cytoskeletal Proteins - physiology
Cytoskeleton - metabolism
Dystroglycans
Laminin - chemistry
Membrane Glycoproteins - chemistry
Membrane Glycoproteins - physiology
Models, Molecular
Protein Binding
Protein Structure, Tertiary
Signal Transduction
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Summary:The notion of dystroglycan as a simple laminin-binding receptor is increasingly being challenged. New roles and new binding partners are continually emerging. Recent structural advances have provided exciting new insights into the precise molecular interactions between dystroglycan and other key components of the dystroglycan complex. Coupled with an increasing understanding of dystroglycan function at the molecular level, we are finally beginning to probe the complexities of dystroglycan, not only in disease, but in development, adhesion and signalling.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0968-0004
1362-4326
DOI:10.1016/S0968-0004(00)01731-X