Monitoring Cortico-cortical Evoked Potentials Using Only Two 6-strand Strip Electrodes for Gliomas Extending to the Dominant Side of Frontal Operculum During One-step Tumor Removal Surgery

• Published in: World neurosurgery Vol. 165; pp. e732 - e742
• Main Authors: Saito, Taiichi, Muragaki, Yoshihiro, Tamura, Manabu, Maruyama, Takashi, Nitta, Masayuki, Tsuzuki, Shunsuke, Fukui, Atsushi, Koriyama, Shunichi, Kawamata, Takakazu
• Format: Journal Article
• Language: English
• Published: United States 01.09.2022
• Subjects: Brain Mapping - methods; Brain Neoplasms - pathology; Electric Stimulation - methods; Electrodes; Evoked Potentials - physiology; Glioma - surgery; Humans; Cortico-cortical evoked potentials; Language function; Awake craniotomy; Glioma; Frontal operculum
• ISSN: 1878-8750; 1878-8769
• DOI: 10.1016/j.wneu.2022.06.141

Resection of the dominant side of gliomas extending to the frontal operculum has high risk of severe language dysfunction. Here, we report recording cortico-cortical evoked potentials (CCEP) using only two 6-strand strip electrodes to monitor language-related fibers intraoperatively. We examined whether this simple procedure is useful for removing gliomas extending to the dominant side of frontal operculum. This study included 7 cases of glioma extending to the left frontal operculum. The frontal language area (FLA) was first identified by functional mapping during awake craniotomy. Next, a 6-strand strip electrode was placed on the FLA, while on the temporal side, an electrode was placed so as to slide parallel to the sylvian fissure toward the posterior language area. Electrical stimulation was performed using the electrode on the frontal side, and CCEPs were measured from the electrode on the temporal side. CCEPs were detected in all cases. Immediately after surgery, all patients demonstrated language dysfunction to varying degree. CCEP decreased to 10% in 1 patient, who recovered language function after 24 months. CCEP decreased slightly 80% in 1, and, in the 5 other cases, CCEPs did not change. These 5 patients soon recovered language function within 2 weeks to 1 month. This study confirmed the utility of CCEP monitoring using only two 6-strand strip electrodes during one-step surgery. We believe this simple method helped in monitoring intraoperative language function and predicting its postoperative recovery in patients with gliomas extending to the dominant side of frontal operculum.