The influence of hydrodynamic conditions and chamber geometry on the analytical signal from integrated biochips

The integration of a biochip with a PDMS fluidic chamber was accomplished. The advantage of dynamic analyte flows, versus static ones, was experimentally demonstrated. This was further clarified by numerical simulation including the approximate mathematical solutions modelling the convective motion...

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Published inJournal of physics. Conference series Vol. 1135; no. 1; pp. 12021 - 12026
Main Authors Esikova, N A, Bulyanitsa, A L, Klotchenko, S A, Taraskin, A S, Evstrapov, A A
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.12.2018
Subjects
Antibodies
Biochips
Chambers
Mathematical models
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Summary:The integration of a biochip with a PDMS fluidic chamber was accomplished. The advantage of dynamic analyte flows, versus static ones, was experimentally demonstrated. This was further clarified by numerical simulation including the approximate mathematical solutions modelling the convective motion and the biotinylated antibody-streptavidin interaction. The possibility of influenza virus A/California/07/09 (H1N1)pdm09 detection by the proposed method was demonstrated.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1135/1/012021