P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin
We have shown recently that mouse Th1 cells but not Th2 cells are selectively recruited into inflamed sites of a delayed-type hypersensitivity (DTH) reaction of the skin. This migration was blocked by monoclonal antibodies (mAb) against P- and E-selectin. Here we show that Th1 cells bind to P-select...
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| Published in | The Journal of experimental medicine Vol. 185; no. 3; pp. 573 - 578 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
The Rockefeller University Press
03.02.1997
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| Subjects | |
| Online Access | Get full text |
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| Abstract | We have shown recently that mouse Th1 cells but not Th2 cells are selectively recruited into inflamed sites of a delayed-type hypersensitivity (DTH) reaction of the skin. This migration was blocked by monoclonal antibodies (mAb) against P- and E-selectin. Here we show that Th1 cells bind to P-selectin via the P-selectin glycoprotein ligand-1 (PSGL-1). This is the only glycoprotein ligand that was detectable by affinity isolation with a P-selectin-Ig fusion protein. Binding of Th1 cells to P-selectin, as analyzed by flow cytometry and in cell adhesion assays, was completely blocked by antibodies against PSGL-1. The same antibodies blocked partially the migration of Th1 cells into cutaneous DTH reactions. This blocking activity, in combination with that of a mAb against E-selectin, was additive. PSGL-1 on Th2 cells, although expressed at similar levels as on Th1 cells, did not support binding to P-selectin. Thus, the P-selectin-binding form of PSGL-1 distinguishes Th1 cells from Th2 cells. Furthermore, PSGL-1 is relevant for the entry of Th1 cells into inflamed areas of the skin. This is the first demonstration for the importance of PSGL-1 for mouse leukocyte recruitment in vivo. |
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| AbstractList | We have shown recently that mouse Th1 cells but not Th2 cells are selectively recruited into inflamed sites of a delayed-type hypersensitivity (DTH) reaction of the skin. This migration was blocked by monoclonal antibodies (mAb) against P- and E-selectin. Here we show that Th1 cells bind to P-selectin via the P-selectin glycoprotein ligand-1 (PSGL-1). This is the only glycoprotein ligand that was detectable by affinity isolation with a P-selectin-Ig fusion protein. Binding of Th1 cells to P-selectin, as analyzed by flow cytometry and in cell adhesion assays, was completely blocked by antibodies against PSGL-1. The same antibodies blocked partially the migration of Th1 cells into cutaneous DTH reactions. This blocking activity, in combination with that of a mAb against E-selectin, was additive. PSGL-1 on Th2 cells, although expressed at similar levels as on Th1 cells, did not support binding to P-selectin. Thus, the P-selectin-binding form of PSGL-1 distinguishes Th1 cells from Th2 cells. Furthermore, PSGL-1 is relevant for the entry of Th1 cells into inflamed areas of the skin. This is the first demonstration for the importance of PSGL-1 for mouse leukocyte recruitment in vivo. |
| Author | Hallmann, R Moll, T Borges, E Vestweber, D Tietz, W Steegmaier, M Hamann, A |
| AuthorAffiliation | From the Institut für Zellbiologie, ZMBE, Universität Münster, Germany; ‡ Abteilung für Immunologie, Medizinische Klinik, Universitätskrankenhaus Eppendorf, Hamburg, Germany; § Institut für Exp. Medizin u. Bindegewebsforschung, Universität Erlangen-Nürnberg, Germany |
| AuthorAffiliation_xml | – name: From the Institut für Zellbiologie, ZMBE, Universität Münster, Germany; ‡ Abteilung für Immunologie, Medizinische Klinik, Universitätskrankenhaus Eppendorf, Hamburg, Germany; § Institut für Exp. Medizin u. Bindegewebsforschung, Universität Erlangen-Nürnberg, Germany |
| Author_xml | – sequence: 1 givenname: E surname: Borges fullname: Borges, E organization: Institut für Zellbiologie, ZMBE, Universität Münster, Germany – sequence: 2 givenname: W surname: Tietz fullname: Tietz, W – sequence: 3 givenname: M surname: Steegmaier fullname: Steegmaier, M – sequence: 4 givenname: T surname: Moll fullname: Moll, T – sequence: 5 givenname: R surname: Hallmann fullname: Hallmann, R – sequence: 6 givenname: A surname: Hamann fullname: Hamann, A – sequence: 7 givenname: D surname: Vestweber fullname: Vestweber, D |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9053457$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | AIDS/HIV Animals Brief Definitive Report Cell Movement Cells, Cultured Dermatitis - immunology Membrane Glycoproteins - physiology Mice Mice, Inbred BALB C P-Selectin - metabolism Th1 Cells - physiology Th2 Cells - physiology |
| Title | P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin |
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