Uncovering the Neural Mechanisms of Inter-Hemispheric Balance Restoration in Chronic Stroke through EMG-Driven Robot Hand Training: Insights from Dynamic Causal Modeling

• Published in: IEEE transactions on neural systems and rehabilitation engineering Vol. 32; p. 1
• Main Authors: Ti, Chun-hang Eden, Hu, Chengpeng, Yuan, Kai, Chu, Winnie Chiu-wing, Tong, Raymond Kai-yu
• Format: Journal Article
• Language: English
• Published: United States IEEE 01.01.2024; The Institute of Electrical and Electronics Engineers, Inc. (IEEE)
• Subjects: Arm; Brain modeling; Cerebral hemispheres; Chronic Stroke; Cortex (motor); Cortex (premotor); Dynamic Causal Modeling; Effective connectivity; Electromyography; End effectors; Functional magnetic resonance imaging; Hand; Humans; Interhemispheric; Magnetic Resonance Imaging; Modelling; Motor Cortex - physiology; Primary motor cortex; Recovery; Recovery of function; Reduction; Resting-state functional connectivity; Restoration; Robot kinematics; Robotics; Robots; Stroke; Supplementary motor area; Task analysis; Training
• ISSN: 1534-4320; 1558-0210; 1558-0210
• DOI: 10.1109/TNSRE.2023.3339756

EMG-driven robot hand training can facilitate motor recovery in chronic stroke patients by restoring the interhemispheric balance between motor networks. However, the underlying mechanisms of reorganization between interhemispheric regions remain unclear. This study investigated the effective connectivity (EC) between the ventral premotor cortex (PMv), supplementary motor area (SMA), and primary motor cortex (M1) using Dynamic Causal Modeling (DCM) during motor tasks with the paretic hand. Nineteen chronic stroke subjects underwent 20 sessions of EMG-driven robot hand training, and their Action Reach Arm Test (ARAT) showed significant improvement (β=3.56, p<0.001). The improvement was correlated with the reduction of inhibitory coupling from the contralesional M1 to the ipsilesional M1 (r=0.58, p=0.014). An increase in the laterality index was only observed in homotopic M1, but not in the premotor area. Additionally, we identified an increase in resting-state functional connectivity (FC) between bilateral M1 (β=0.11, p=0.01). Inter-M1 FC demonstrated marginal positive relationships with ARAT scores (r=0.402, p=0.110), but its changes did not correlate with ARAT improvements. These findings suggest that the improvement of hand functions brought about by EMG-driven robot hand training was driven explicitly by task-specific reorganization of motor networks. Particularly, the restoration of interhemispheric balance was induced by a reduction in interhemispheric inhibition from the contralesional M1 during motor tasks of the paretic hand. This finding sheds light on the mechanistic understanding of interhemispheric balance and functional recovery induced by EMG-driven robot training.