Dermatophyte infection: from fungal pathogenicity to host immune responses

Dermatophytosis is a common superficial infection caused by dermatophytes, a group of pathogenic keratinophilic fungi. Apart from invasion against skin barrier, host immune responses to dermatophytes could also lead to pathologic inflammation and tissue damage to some extent. Therefore, it is of gre...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in immunology Vol. 14; p. 1285887
Main Authors Deng, Ruixin, Wang, Xiaowen, Li, Ruoyu
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 2023
Subjects
Arthrodermataceae
caspase-associated recruitment domain 9
Dermatomycoses
dermatophyte
Humans
Immunity
innate immune response
pattern recognition receptors
protease
Tinea - microbiology
type 1 immune response
Virulence
pattern recognition receptors
protease
dermatophyte
innate immune response
type 1 immune response
type 17 immune response
caspase-associated recruitment domain 9
Online AccessGet full text

Cover

More Information
Summary:Dermatophytosis is a common superficial infection caused by dermatophytes, a group of pathogenic keratinophilic fungi. Apart from invasion against skin barrier, host immune responses to dermatophytes could also lead to pathologic inflammation and tissue damage to some extent. Therefore, it is of great help to understand the pathogenesis of dermatophytes, including fungal virulence factors and anti-pathogen immune responses. This review aims to summarize the recent advances in host-fungal interactions, focusing on the mechanisms of anti-fungal immunity and the relationship between immune deficiency and chronic dermatophytosis, in order to facilitate novel diagnostic and therapeutic approaches to improve the outcomes of these patients.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Commentary-4
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1285887