Harnessing Information Thermodynamics: Conversion of DNA Information into Mechanical Work in RNA Transcription and Nanopore Sequencing

Recent advancements in information thermodynamics have revealed that information can be directly converted into mechanical work. Specifically, RNA transcription and nanopore sequencing serve as prime examples of this conversion, by reading information from a DNA template. This paper introduces an in...

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Bibliographic Details
Published inEntropy (Basel, Switzerland) Vol. 26; no. 4; p. 324
Main Author Tsuruyama, Tatsuaki
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.04.2024
Subjects
Adenosine triphosphatase
Brownian motion
Data processing
Deoxyribonucleic acid
DNA
DNA sequencing
Error reduction
fluctuation theorem
Fokker-Planck equation
free energy change
Gene sequencing
Genetic research
Genetic transcription
Molecular motors
mutual information
nanopore sequencing
Nucleotide sequencing
Probability
Ribonucleic acid
RNA
RNA polymerase
Signal transduction
Thermodynamic models
Thermodynamics
transcription
Japan
nanopore sequencing
free energy change
RNA polymerase
mutual information
fluctuation theorem
transcription
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Summary:Recent advancements in information thermodynamics have revealed that information can be directly converted into mechanical work. Specifically, RNA transcription and nanopore sequencing serve as prime examples of this conversion, by reading information from a DNA template. This paper introduces an information thermodynamic model in which these molecular motors can move along the DNA template by converting the information read from the template DNA into their own motion. This process is a stochastic one, characterized by significant fluctuations in forward movement and is described by the Fokker-Planck equation, based on drift velocity and diffusion coefficients. In the current study, it is hypothesized that by utilizing the sequence information of the template DNA as mutual information, the fluctuations can be reduced, thereby biasing the forward movement on DNA and, consequently, reducing reading errors. Further research into the conversion of biological information by molecular motors could unveil new applications, insights, and important findings regarding the characteristics of information processing in biology.
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ISSN:1099-4300
1099-4300
DOI:10.3390/e26040324