Nickel-Catalyzed Multicomponent Coupling of Alkyne, Buta-1,3-diene, and Dimethylzinc under Carbon Dioxide

A nickel catalyst promoted the coupling of alkynes with buta-1,3-diene and dimethylzinc under carbon dioxide to provide (5E,8Z)-2-vinyldeca-5,8-dienoic acids with high regio- and stereo-selectivity.

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Bibliographic Details
Published inSynthesis (Stuttgart) Vol. 46; no. 17; pp. 2287 - 2292
Main Authors Mori, Yasuyuki, Mori, Takamichi, Onodera, Gen, Kimura, Masanari
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.09.2014
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
nickel
carbon dioxide
3-COMPONENT SYNTHESIS
ISOPRENE
dimethylzinc
1,3-DIENES
STRATEGY
4-COMPONENT CONNECTION
ALDEHYDES
butadiene
1,3-BUTADIENE
alkyne
CARBOXYLATION
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Summary:A nickel catalyst promoted the coupling of alkynes with buta-1,3-diene and dimethylzinc under carbon dioxide to provide (5E,8Z)-2-vinyldeca-5,8-dienoic acids with high regio- and stereo-selectivity.
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0033-1339024