Antiarthritic and antiinflammatory propensity of 4-methylesculetin, a coumarin derivative

• Published in: Biochimie Vol. 95; no. 6; pp. 1326 - 1335
• Main Authors: Hemshekhar, M., Sunitha, K., Thushara, R.M., Sebastin Santhosh, M., Shanmuga Sundaram, M., Kemparaju, K., Girish, K.S.
• Format: Journal Article
• Language: English
• Published: France Elsevier B.V 01.06.2013
• Subjects: 4-Methylesculetin; Animals; Anti-Inflammatory Agents - pharmacology; Arthritis; Arthritis, Experimental - drug therapy; Arthritis, Experimental - pathology; Bone and Bones - drug effects; Bone and Bones - pathology; Cartilage - drug effects; Cartilage - pathology; Cartilage degradation; Coumarins - chemistry; Disease Models, Animal; Inflammation - pathology; Inflammatory mediators; Male; Oxidative stress; Oxidative Stress - drug effects; Rats; Rats, Wistar; Umbelliferones - pharmacology; Oxidative stress; HVA; 4-Methylesculetin; DCF; MMPs; HAases; ROS; Arthritis; Inflammatory mediators; Cartilage degradation

Coumarins are a group of natural compounds widely distributed in plants. Of late, coumarins and their derivatives have grabbed much attention from the pharmacological and pharmaceutical arena due to their broad range of therapeutical qualities. A coumarin derivative 4-methylesculetin (4-ME) has know...