Abacavir: it’s use and hypersensitivity

Abacavir, a nucleoside reverse transcriptase inhibitor, is useful in first- and second-line HIV therapy and as a substitute for stavudine and zidovudine when toxicity is a problem. Although it is safe and well tolerated, a life-threatening hypersensitivity reaction can occur. The risk for developing...

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Bibliographic Details
Published inSouthern African journal of HIV medicine Vol. 10; no. 4; p. 81
Main Authors Rabie, Helena, Henning, Kristin Lorenc, Schoeman, Pierre, de Villiers, Nico, Pretrorius, G.H.J "Oubaas", Cotton, Mark F
Format Journal Article
LanguageEnglish
Published African Online Scientific Information Systems (Pty) Ltd t/a AOSIS 01.12.2009
AOSIS
Subjects
Abacavir
Allergic reaction
Allergy
Complications and side effects
Dosage and administration
Drug therapy
Drug therapy, Combination
HIV infection
Risk factors
South Africa
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Summary:Abacavir, a nucleoside reverse transcriptase inhibitor, is useful in first- and second-line HIV therapy and as a substitute for stavudine and zidovudine when toxicity is a problem. Although it is safe and well tolerated, a life-threatening hypersensitivity reaction can occur. The risk for developing this reaction relates to the presence of specific genotypes, especially HLA-B*5701.
ISSN:1608-9693
2078-6751
DOI:10.4102/sajhivmed.v10i4.265