Neuroleptic malignant syndrome following autologous peripheral blood stem cell transplantation

Neuroleptic malignant syndrome (NMS) is a rare disorder characterized by hyperthermia, elevated creatine phosphokinase, extrapyramidal effects, autonomic instability, altered level of consciousness and leukocytosis associated with neuroleptic and other psychotropic medications. There are no cases of...

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Bibliographic Details
Published inBone marrow transplantation (Basingstoke) Vol. 21; no. 4; pp. 427 - 428
Main Authors GARRIDO, S. M, CHAUNCEY, T. R
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 01.02.1998
Subjects
Antipsychotic Agents - adverse effects
Autografts
Autonomic nervous system
Biological and medical sciences
Breast Neoplasms - therapy
Creatine
Creatine kinase
Droperidol - adverse effects
Drug toxicity and drugs side effects treatment
Extrapyramidal system
Female
Haloperidol - adverse effects
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic stem cells
Humans
Hyperthermia
Leukocytosis
Liposarcoma - therapy
Male
Medical sciences
Middle Aged
Miscellaneous (drug allergy, mutagens, teratogens...)
Morbidity
Neuroleptic Malignant Syndrome - diagnosis
Neuroleptic Malignant Syndrome - etiology
Peripheral blood
Pharmacology. Drug treatments
Prochlorperazine - adverse effects
Stem cell transplantation
Stem cells
Transplantation
Transplantation, Autologous
Human
Neuroleptic
Toxicity
Stem cell
Hematopoietic cell
Male
Blood
Case study
Autograft
Chemotherapy
Treatment
Adult
Complication
Female
Graft
Anxiety
Malignant syndrome
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Summary:Neuroleptic malignant syndrome (NMS) is a rare disorder characterized by hyperthermia, elevated creatine phosphokinase, extrapyramidal effects, autonomic instability, altered level of consciousness and leukocytosis associated with neuroleptic and other psychotropic medications. There are no cases of NMS reported following stem cell transplantation. We describe two patients receiving autotransplants who developed NMS. With the common use of neuroleptic and other related psychotropic medications in the peri-transplant period and the associated physiologic stress of the procedure, we believe that NMS may be unrecognized and account for significant morbidity in this setting.
ISSN:0268-3369
1476-5365
DOI:10.1038/sj.bmt.1701093