Transdermal Fentanyl Solution Provides Long-term Analgesia in the Hind-paw Incisional Model of Postoperative Pain in Male Rats

A recently developed transdermal fentanyl solution was hypothesized to be effective for non-invasive postoperative analgesia in rats. Thirty-nine male Sprague-Dawley rats were treated once with 0.1, 0.33 or 1.0 mg/kg transdermal fentanyl solution at the skin of the scruff 1 h prior to subjected to h...

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Published inIn vivo (Athens) Vol. 32; no. 4; pp. 713 - 719
Main Authors Clemensen, Johanne, Rasmussen, Lena V, Abelson, Klas S P
Format Journal Article
LanguageEnglish
Published Greece International Institute of Anticancer Research 01.07.2018
Subjects
pain
transdermal
Laboratory rats
analgesia
fentanyl
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Summary:A recently developed transdermal fentanyl solution was hypothesized to be effective for non-invasive postoperative analgesia in rats. Thirty-nine male Sprague-Dawley rats were treated once with 0.1, 0.33 or 1.0 mg/kg transdermal fentanyl solution at the skin of the scruff 1 h prior to subjected to hind-paw surgery, and compared to non-treated animals. All rats were tested for nociceptive response in the electronic von Frey (EVF) test between 1 and 72 h postoperatively, and assessed daily with regards to facial expression, body weight changes and welfare score. Fentanyl treatment at all doses significantly reduced nociceptive response in the EVF test throughout the 72 h of experimentation, reduced facial expressions on all days postoperatively, slightly reduced the body weight and improved postoperative welfare parameters. The present study indicates that transdermal fentanyl solution seems to be an effective, non-invasive and long-lasting analgesic regimen in male rats.
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ISSN:0258-851X
1791-7549
DOI:10.21873/invivo.11299