Grand challenges in modulating the immune response with RNAi nanomedicines

RNAi is a ubiquitous and highly specific, endogenous, evolutionarily conserved mechanism of gene silencing. RNAi holds great promise as a novel therapeutic modality. Despite the rapid progress in the understanding and utilization of RNAi in vitro, the application of RNAi in vivo has been met with gr...

Full description

Saved in:
Bibliographic Details
Published inNanomedicine (London, England) Vol. 6; no. 10; pp. 1771 - 1785
Main Authors Goldsmith, Meir, Mizrahy, Shoshy, Peer, Dan
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.12.2011
Subjects
Evolution
Gene silencing
Gene Silencing - physiology
Humans
Immune response
Immunity, Cellular - genetics
Immunity, Cellular - immunology
Leukocytes
Leukocytes - immunology
Liposomes
Liposomes - chemistry
Nanomedicine
Nanomedicine - instrumentation
Nanomedicine - methods
Physiological aspects
RNA Interference - physiology
RNA, Small Interfering - administration & dosage
RNA, Small Interfering - chemistry
RNA-mediated interference
Israel
Online AccessGet full text

Cover

More Information
Summary:RNAi is a ubiquitous and highly specific, endogenous, evolutionarily conserved mechanism of gene silencing. RNAi holds great promise as a novel therapeutic modality. Despite the rapid progress in the understanding and utilization of RNAi in vitro, the application of RNAi in vivo has been met with great difficulties, mainly in the delivery of these molecules into specific cell types. Here, we describe the major systemic nanomedicine platforms that have been developed. Focus is given to the development of new strategies to target subsets of leukocytes, which are among the most difficult cells to transduce with RNAi. Finally, we discuss the hurdles and potential opportunities for in vivo manipulation of the immune response utilizing RNAi nanomedicines.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm.11.162