Classical and non-classical congenital adrenal hyperplasia: What is the difference in subsequent fertility?

21-Hydroxylase deficiency (21OHD) is the most common cause of congenital adrenal hyperplasia. Increased production of adrenal-derived androgens and progesterone in 21OHD women interfere with their reproductive function and their fertility in many different ways, depending on the severity of the dise...

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Bibliographic Details
Published inAnnales d'endocrinologie Vol. 83; no. 3; pp. 181 - 185
Main Authors Carrière, Camille, Sarfati, Cynthia, Téjédor, Isabelle, Dulon, Jérôme, Chakhtoura, Zeina, Courtillot, Carine, Bachelot, Anne
Format Journal Article
LanguageEnglish
Published France Elsevier Masson SAS 01.06.2022
Subjects
21 hydroxylase deficiency
Adrenal Hyperplasia, Congenital - complications
Adrenal Hyperplasia, Congenital - genetics
Androgens
Congenital adrenal hyperplasia
Endocrinology and Metabolism
Female
Fertility
Gonadotrophs
Humans
Internal Medicine
Pregnancy
Progesterone
Steroid 21-Hydroxylase - genetics
Pregnancy
21 hydroxylase deficiency
Congenital adrenal hyperplasia
Fertility
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Summary:21-Hydroxylase deficiency (21OHD) is the most common cause of congenital adrenal hyperplasia. Increased production of adrenal-derived androgens and progesterone in 21OHD women interfere with their reproductive function and their fertility in many different ways, depending on the severity of the disease. Sexuality and fertility in women with classic 21OHD is impaired, due to several issues such as disrupted gonadotropic axis due to androgen and progesterone overproduction, and mechanical, psychological factors related to genital surgery. Fertility and fecundity in these women get better over the years. Subfertility seems contrariwise to be relative in non-classic 21OHD women. Before pregnancy, genotyping the partner and genetic counselling is mandatory.
ISSN:0003-4266
2213-3941
DOI:10.1016/j.ando.2022.04.007