Autonomous robot-aided optical tweezer system for biological cell manipulation

Over the past few decades, optical tweezers have become a powerful tool that is widely used in cell-based biomedical applications. Their popularity is attributed to their unique advantages in the manipulation of biological cells with high accuracy, degree of freedom, and flexibility in a noninvasive...

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Bibliographic Details
Published inInternational journal of advanced manufacturing technology Vol. 105; no. 12; pp. 4953 - 4966
Main Author Xie, Mingyang
Format Journal Article
LanguageEnglish
Published London Springer London 01.12.2019
Springer Nature B.V
Subjects
Automation
Biological activity
Biomedical materials
CAE) and Design
Computer-Aided Engineering (CAD
Engineering
Industrial and Production Engineering
Mechanical Engineering
Media Management
Original Article
Trends
Optical tweezer
Autonomous cell manipulation
Cell transportation
Cell rotation
Cell surgery
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Summary:Over the past few decades, optical tweezers have become a powerful tool that is widely used in cell-based biomedical applications. Their popularity is attributed to their unique advantages in the manipulation of biological cells with high accuracy, degree of freedom, and flexibility in a noninvasive manner. With the trends toward the automation of biological processes with high throughput, precision, and reliability, many autonomous frameworks have been developed for the realization of diverse cell manipulations. This study reviews the latest advancements in automated cell transportation and reorientation control. Moreover, by integrating optical tweezers with other tools, the mechanisms of cell-based physiological activity and subcellular operation are investigated and reviewed. Discussions on the current challenges and potential research trends on optical manipulation of biological cells are finally presented.
ISSN:0268-3768
1433-3015
DOI:10.1007/s00170-019-04683-1