A pharmacological link between epilepsy and anxiety?
Clinical and experimental evidence suggests a relationship between two important pathological traits, epilepsy and anxiety, that might involve the GABA A receptor. To demonstrate a direct link, anxiogenic responses induced by a benzodiazepine receptor ligand have been assessed in mice selected for t...
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Published in | Trends in pharmacological sciences (Regular ed.) Vol. 22; no. 10; pp. 491 - 493 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.10.2001
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Subjects | |
Online Access | Get full text |
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Summary: | Clinical and experimental evidence suggests a relationship between two important pathological traits, epilepsy and anxiety, that might involve the GABA
A receptor. To demonstrate a direct link, anxiogenic responses induced by a benzodiazepine receptor ligand have been assessed in mice selected for their sensitivity to epilepsy. The results provided evidence for a link between seizuring and anxiety, but showed no direct involvement of GABA
A receptors. |
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ISSN: | 0165-6147 1873-3735 |
DOI: | 10.1016/S0165-6147(00)01807-1 |