A pharmacological link between epilepsy and anxiety?

Clinical and experimental evidence suggests a relationship between two important pathological traits, epilepsy and anxiety, that might involve the GABA A receptor. To demonstrate a direct link, anxiogenic responses induced by a benzodiazepine receptor ligand have been assessed in mice selected for t...

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Bibliographic Details
Published inTrends in pharmacological sciences (Regular ed.) Vol. 22; no. 10; pp. 491 - 493
Main Authors Chapouthier, Georges, Venault, Patrice
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2001
Subjects
Animals
anxiety
Anxiety - chemically induced
Anxiety - genetics
Anxiety - metabolism
benzodiazepine
Carbolines - adverse effects
Convulsants - adverse effects
epilepsy
Epilepsy - genetics
Epilepsy - metabolism
GABA
genetics
Mice
selectively bred mice
Species Specificity
epilepsy
anxiety
genetics
GABA
Pharmacology
selectively bred mice
benzodiazepine
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Summary:Clinical and experimental evidence suggests a relationship between two important pathological traits, epilepsy and anxiety, that might involve the GABA A receptor. To demonstrate a direct link, anxiogenic responses induced by a benzodiazepine receptor ligand have been assessed in mice selected for their sensitivity to epilepsy. The results provided evidence for a link between seizuring and anxiety, but showed no direct involvement of GABA A receptors.
ISSN:0165-6147
1873-3735
DOI:10.1016/S0165-6147(00)01807-1