Large-scale sources of neural stem cells

• Published in: Annual review of neuroscience Vol. 25; no. 1; pp. 381 - 407
• Main Author: GOTTLIEB, David I
• Format: Journal Article
• Language: English
• Published: Palo Alto, CA Annual Reviews 01.01.2002
• Subjects: Animals; Biological and medical sciences; Brain Tissue Transplantation - methods; Cell Culture Techniques - methods; Cell Culture Techniques - trends; Cell Differentiation - physiology; Cell Line - classification; Cell Line - cytology; Cell Line - transplantation; Development. Senescence. Regeneration. Transplantation; Fundamental and applied biological sciences. Psychology; Humans; Neuroglia - cytology; Neuroglia - transplantation; Neurons - cytology; Neurons - transplantation; Spheroids, Cellular - cytology; Spheroids, Cellular - transplantation; Stem Cell Transplantation; Stem Cells - cytology; Tumor Cells, Cultured - classification; Tumor Cells, Cultured - cytology; Tumor Cells, Cultured - transplantation; Vertebrates: nervous system and sense organs; Development; Nervous system; Cell line; Review; Differentiation; Stem cell
• ISSN: 0147-006X; 1545-4126
• DOI: 10.1146/annurev.neuro.25.112701.142904

Large-scale sources of neural stem cells are crucial for both basic research and novel approaches toward treating neurological disorders. Three sources that produce neural cells closely resembling their normal counterparts are now available: oncogene immortalized stem cells, neurospheres, and embryonic stem cell (ES)-derived neural cells. Cells including multiple subtypes of CNS and PNS neurons, as well as oligodendrocytes, Schwann cells, and astrocytes, are modeled by these large-scale sources. Although most cell lines were originally from rodents, their human counterparts are being discovered and characterized.