Advances in the application of electrohydrodynamic fabrication for tissue engineering

Tissue engineering and cell-based therapy approaches require artificial scaffolds as extracellular matrix (ECM) and three-dimensional (3D) environment for clinically relevant cells to attach, be metabolically active and proliferate. Moreover, these constructs must possess mechanical and physical-che...

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Published inJournal of physics. Conference series Vol. 1236; no. 1; pp. 12024 - 12029
Main Authors Gryshkov, O, Müller, M, Leal-Marin, S, Mutsenko, V, Suresh, S, Kapralova, V M, Glasmacher, B
Format Journal Article
LanguageEnglish
Published Bristol IOP Publishing 01.06.2019
Subjects
Chemical properties
Electric fields
Electrohydrodynamics
Hydrogels
Implantation
Physics
Scaffolds
Tissue engineering
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Summary:Tissue engineering and cell-based therapy approaches require artificial scaffolds as extracellular matrix (ECM) and three-dimensional (3D) environment for clinically relevant cells to attach, be metabolically active and proliferate. Moreover, these constructs must possess mechanical and physical-chemical properties matched with certain implantation site. If all the required conditions are met, a tissue-engineered construct is considered as functional and will regenerate or replace the damaged tissue after implantation. In this work, we give a short overview of so-called electrohydrodynamic approach (EHD), e.g. with an application of electric field, to fabricate nano- and microstructured porous polymeric networks. This includes the application of electrospinning (networks) and electrospraying (micro- and macrospheres) to produce scaffolds and semipermeable hydrogel structures as a basis for tissue engineering and cell-based therapies.
ISSN:1742-6588
1742-6596
DOI:10.1088/1742-6596/1236/1/012024