Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes

• Published in: Gene Vol. 499; no. 1; pp. 226 - 230
• Main Authors: Nishio, Naoki, Teranishi, Masaaki, Uchida, Yasue, Sugiura, Saiko, Ando, Fujiko, Shimokata, Hiroshi, Sone, Michihiko, Otake, Hironao, Kato, Ken, Yoshida, Tadao, Tagaya, Mitsuhiko, Hibi, Tatsuya, Nakashima, Tsutomu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.05.2012
• Subjects: Adult; Aged; Aged, 80 and over; alleles; Amino Acid Substitution; Amino Acid Substitution - genetics; Amino Acid Substitution - physiology; Case-Control Studies; CFH Y402H; complement; Complement Factor H; Complement Factor H - genetics; complications; confidence interval; Diabetes; Diabetes Complications; Diabetes Complications - genetics; etiology; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; genetics; hearing; Hearing Loss, Sensorineural; Hearing Loss, Sensorineural - complications; Hearing Loss, Sensorineural - genetics; Hearing Loss, Sudden; Hearing Loss, Sudden - complications; Hearing Loss, Sudden - genetics; Histidine; Histidine - genetics; Humans; hyperlipidemia; hypertension; macular degeneration; Male; Middle Aged; odds ratio; patients; physiology; Polymorphism; Polymorphism, Single Nucleotide; Polymorphism, Single Nucleotide - physiology; risk; Sudden sensorineural hearing loss; Tyrosine; Tyrosine - genetics; Young Adult; CRP; OR; CFH; SAS; CFH Y402H; CI; aHUS; MPGN2; SSNHL; Sudden sensorineural hearing loss; Complement factor H; NILS-LSA; AMD; Diabetes; PCR; Polymorphism
• ISSN: 0378-1119; 1879-0038; 1879-0038
• DOI: 10.1016/j.gene.2012.02.027

Sudden sensorineural hearing loss (SSNHL) is one of the most common diseases encountered by otolaryngologists; however, the etiology is unclear. The aim of this study was to assess the association between SSNHL and polymorphism of complement factor H (CFH) Y402H, which is implicated in age-related macular degeneration. We conducted a case–control study, in which the cases were 72 SSNHL patients and the controls were 2161 residents selected randomly from the resident register. The odds ratio (OR) for SSNHL risk was determined using the additive-genetic model of CFH Y402H polymorphism. The OR for SSNHL risk was 1.788 (95% confidence interval [CI]: 1.008–3.172) with no adjustments and 1.820 (CI: 1.025–3.232) after adjusting for age and sex. Of the three lifestyle-related diseases hypertension, dyslipidemia, and diabetes, only diabetes was significantly associated with SSNHL risk. We classified both the controls and SSNHL patients into those with or without diabetes, and the OR for SSNHL risk was 6.326 (CI: 1.885–21.225) in diabetic subjects and 1.214 (CI: 0.581–2.538) in nondiabetic subjects. We conclude that CFH Y402H polymorphism and SSNHL risk are significantly related, and that diabetic CFH Y402H minor allele carriers may be susceptible to SSNHL. ► We studied the association between SSNHL and CFH Y402H polymorphism. ► We conducted a case–control study. ► The cases were 72 SSNHL patients and the controls were 2161 residents. ► CFH Y402H polymorphism and SSNHL risk are significantly related. ► Diabetic CFH Y402H minor allele carriers may be susceptible to SSNHL.