Inherited hemolytic uremic syndrome in adults

Familial hemolytic uremic syndrome (HUS) in children may be due to environmental factors or may be an inherited trait, usually with autosomal recessive inheritance. Familial HUS in adults is less well described, and can be associated with autosomal recessive or dominant inheritance. We report a fami...

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Bibliographic Details
Published inAmerican journal of kidney diseases Vol. 19; no. 4; p. 331
Main Authors Berns, J S, Kaplan, B S, Mackow, R C, Hefter, L G
Format Journal Article
LanguageEnglish
Published United States 01.04.1992
Subjects
Adult
Contraceptives, Oral - adverse effects
Female
Hemolytic-Uremic Syndrome - epidemiology
Hemolytic-Uremic Syndrome - etiology
Hemolytic-Uremic Syndrome - genetics
Humans
Kidney - pathology
Male
Pregnancy
Pregnancy Complications, Hematologic - epidemiology
Prognosis
Risk Factors
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Summary:Familial hemolytic uremic syndrome (HUS) in children may be due to environmental factors or may be an inherited trait, usually with autosomal recessive inheritance. Familial HUS in adults is less well described, and can be associated with autosomal recessive or dominant inheritance. We report a family with autosomal dominant inheritance of HUS. The proband was an adult male. His adult sister developed HUS while taking oral contraceptives, and their mother developed HUS during the third trimester of pregnancy. The prognosis for these patients is poor. Pregnancy and oral contraceptive use may be risk factors for development of HUS in adult women with a family history of HUS or the related disorder thrombotic thrombocytopenic purpura (TTP).
ISSN:0272-6386
DOI:10.1016/S0272-6386(12)80449-5