Association study of polymorphisms in N-methyl- d-aspartate receptor 2B subunits (GRIN2B) gene with Korean alcoholism

• Published in: Neuroscience research Vol. 56; no. 2; pp. 220 - 223
• Main Authors: Kim, Jin Hee, Park, Mira, Yang, So Young, Jeong, Bum Seok, Yoo, Hee Jeong, Kim, Jong-Woo, Chung, Joo-Ho, Kim, Soon Ae
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.10.2006
• Subjects: Adult; Aged; Alcoholism; Alcoholism - epidemiology; Alcoholism - genetics; Association; Chi-Square Distribution; DNA Mutational Analysis - methods; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; GRIN2B; Haplotype; Humans; Korea - epidemiology; Linkage Disequilibrium; Male; Middle Aged; N-Methyl- d-aspartate (NMDA) receptor 2B gene ( NR2B; Polymorphism; Polymorphism, Genetic; Receptors, N-Methyl-D-Aspartate - genetics; Reverse Transcriptase Polymerase Chain Reaction - methods; Korea; N-Methyl- d-aspartate (NMDA) receptor 2B gene ( NR2B; Association; GRIN2B; Haplotype; Alcoholism; Polymorphism
• ISSN: 0168-0102; 1872-8111
• DOI: 10.1016/j.neures.2006.06.013

The N-methyl- d-aspartate (NMDA) receptor 2B gene ( GRIN2B) was studied as a candidate gene of alcoholism. This study aimed to investigate the association between each of the three GRIN2B polymorphisms (rs1806201, rs1805247, and rs1805502) and alcoholism. This study included 206 alcoholic patients and 189 unrelated control subjects of Korean origin. Associations between genotype, allele, and haplotype frequencies of the polymorphisms and alcoholism were investigated. The genotype frequencies of rs1806201 and the haplotype analysis of SNPs in this study show significantly differences between the case and controls. These findings suggest new candidate SNPs in GRIN2B for studying the genetic susceptibility to alcoholism.