Research on Microfluidic Chip Design and Droplet Related Technology

• Published in: Journal of physics. Conference series Vol. 1520; no. 1; pp. 12003 - 12009
• Main Authors: Zhen, Su, XiaoMing, Han, QuanJun, Liu
• Format: Journal Article
• Language: English
• Published: Bristol IOP Publishing 01.04.2020
• Subjects: Constant pressure pump; Design; Dispersion; Droplet; Droplet fusion; Droplets; Flow velocity; Liquid flow; Microfluidic Chips; Microfluidic devices; Microreactors; PDMS; Physics; Reagents
• ISSN: 1742-6588; 1742-6596
• DOI: 10.1088/1742-6596/1520/1/012003

Microfluidic Chips, also known as chip labs, integrate basic operating units in the fields of chemistry and biology on a chip. The droplet is a technique for controlling a small volume of liquid on a microfluidic chip. One of the two incompatible liquids is used as one continuous phase and the other as a dispersed phase, and the dispersed phase is dispersed in a continuous phase in a micro volume unit. Droplet fusion is the basic tool for controlling droplets in microfluidic devices and their use as microreactors, allowing precise mixing of reagents and fusion of samples at well-defined points in space and time.This topic is based on microfluidic technology, designed and processed PDMS chip, research on droplet generation and droplet fusion technology in microfluidic chip. Using a constant pressure pump designed by the laboratory to drive the sample injection, study the effects of continuous phase, discrete phase convergence angle, flow path width, liquid flow rate, etc. on the droplet formation of the cross-shaped structure. Based on the droplet generation technology, The subject then studied the droplet fusion technology, completed the droplet fusion chip design and processing, and achieved 1:1 1:2 fusion of two sample droplets.