Preparation of the individual diastereomers of adenylyl-(2'-5')-P-thioadenylyl-(2'-5')-adenosine and their 5'-phosphorylated derivatives

The individual diastereomers of trimer A2'p5'A2'p(s)5'A, containing one phosphorothioate linkage, were prepared via a modified hydroxybenzotriazole phosphotriester approach. The 5'-phosphorylated derivatives of the latter compounds were obtained after phosphorylation with a...

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Published inNucleic acids research Vol. 15; no. 23; pp. 9933 - 9943
Main Authors DE VROOM, E, FIDDER, A, SARIS, C. P, VAN DER MAREL, G. A, VAN BOOM, J. H
Format Journal Article
LanguageEnglish
Published Oxford Oxford University Press 10.12.1987
Subjects
Adenine Nucleotides - chemical synthesis
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Cross-Linking Reagents
Fundamental and applied biological sciences. Psychology
Nucleic Acid Conformation
Nucleic acids
Oligoribonucleotides - analogs & derivatives
Oligoribonucleotides - chemical synthesis
Phosphorylation
Rna, ribonucleoproteins
Stereoisomerism
Phosphorylation
Preparation
Diastereomer
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Summary:The individual diastereomers of trimer A2'p5'A2'p(s)5'A, containing one phosphorothioate linkage, were prepared via a modified hydroxybenzotriazole phosphotriester approach. The 5'-phosphorylated derivatives of the latter compounds were obtained after phosphorylation with a 6-trifluoromethyl-1-benzotriazolyl activated phosphoromorpholidate.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/15.23.9933