Short fiber bundle filtering and test-retest reproducibility of the Superficial White Matter

• Published in: Frontiers in neuroscience Vol. 18; p. 1394681
• Main Authors: Mendoza, Cristóbal, Román, Claudio, Mangin, Jean-François, Hernández, Cecilia, Guevara, Pamela
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 2024
• Subjects: diffusion-weighted imaging; fiber bundle segmentation; spurious fibers; Superficial White Matter; tractography; fiber bundle segmentation; tractography; Superficial White Matter; spurious fibers; diffusion-weighted imaging
• ISSN: 1662-453X; 1662-4548; 1662-453X
• DOI: 10.3389/fnins.2024.1394681

In recent years, there has been a growing interest in studying the Superficial White Matter (SWM). The SWM consists of short association fibers connecting near giry of the cortex, with a complex organization due to their close relationship with the cortical folding patterns. Therefore, their segmentation from dMRI tractography datasets requires dedicated methodologies to identify the main fiber bundle shape and deal with spurious fibers. This paper presents an enhanced short fiber bundle segmentation based on a SWM bundle atlas and the filtering of noisy fibers. The method was tuned and evaluated over HCP test-retest probabilistic tractography datasets (44 subjects). We propose four fiber bundle filters to remove spurious fibers. Furthermore, we include the identification of the main fiber fascicle to obtain well-defined fiber bundles. First, we identified four main bundle shapes in the SWM atlas, and performed a filter tuning in a subset of 28 subjects. The filter based on the Convex Hull provided the highest similarity between corresponding test-retest fiber bundles. Subsequently, we applied the best filter in the 16 remaining subjects for all atlas bundles, showing that filtered fiber bundles significantly improve test-retest reproducibility indices when removing between ten and twenty percent of the fibers. Additionally, we applied the bundle segmentation with and without filtering to the ABIDE-II database. The fiber bundle filtering allowed us to obtain a higher number of bundles with significant differences in fractional anisotropy, mean diffusivity, and radial diffusivity of Autism Spectrum Disorder patients relative to controls.