Mechanisms underlying episodic gonadotropin-releasing hormone secretion

• Published in: Frontiers in neuroendocrinology Vol. 24; no. 2; pp. 79 - 93
• Main Authors: Moenter, Suzanne M., Anthony DeFazio, R., Pitts, Gilbert R., Nunemaker, Craig S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2003
• Subjects: Animals; Biological Clocks - physiology; Burst; Calcium; Cells, Cultured; Electrophysiology; Endogenous; Female; Gene Expression Regulation; GnRH; Gonadotropin-Releasing Hormone - secretion; GT1 cell; Male; Mice; Models, Biological; Network; Neurons - metabolism; Oscillator; Periodicity; Pituitary Gland - metabolism; Pulsatile; Rats; Rhythm; Synchronize; Endogenous; GT1 cell; Pulsatile; Calcium; Oscillator; Network; Synchronize; Burst; Rhythm; GnRH

The episodic secretion of gonadotropin-releasing hormone (GnRH) is crucial for fertility, but the cellular mechanisms and network properties generating GnRH pulses are not well understood. We will explore three primary aspects of this intermittent hormonal signal: the source of rhythm(s), the possib...