Mechanisms underlying episodic gonadotropin-releasing hormone secretion

The episodic secretion of gonadotropin-releasing hormone (GnRH) is crucial for fertility, but the cellular mechanisms and network properties generating GnRH pulses are not well understood. We will explore three primary aspects of this intermittent hormonal signal: the source of rhythm(s), the possib...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in neuroendocrinology Vol. 24; no. 2; pp. 79 - 93
Main Authors Moenter, Suzanne M., Anthony DeFazio, R., Pitts, Gilbert R., Nunemaker, Craig S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2003
Subjects
Animals
Biological Clocks - physiology
Burst
Calcium
Cells, Cultured
Electrophysiology
Endogenous
Female
Gene Expression Regulation
GnRH
Gonadotropin-Releasing Hormone - secretion
GT1 cell
Male
Mice
Models, Biological
Network
Neurons - metabolism
Oscillator
Periodicity
Pituitary Gland - metabolism
Pulsatile
Rats
Rhythm
Synchronize
Endogenous
GT1 cell
Pulsatile
Calcium
Oscillator
Network
Synchronize
Burst
Rhythm
GnRH
Online AccessGet full text

Cover

More Information
Summary:The episodic secretion of gonadotropin-releasing hormone (GnRH) is crucial for fertility, but the cellular mechanisms and network properties generating GnRH pulses are not well understood. We will explore three primary aspects of this intermittent hormonal signal: the source of rhythm(s), the possible mechanisms comprising oscillator(s), and how GnRH neurons are synchronized to produce a pulse of hormone release into the pituitary portal blood. Current knowledge will be reviewed, and hypotheses and working models proposed for future studies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0091-3022
1095-6808
DOI:10.1016/S0091-3022(03)00013-X