Copper(I)-Catalyzed Carbometalation of Nonfunctionalized Cyclopropenes Using Organozinc and Grignard Reagents

A highly efficient method was developed for the copper(I)-catalyzed carbometalation of various nonfunctionalized and functionalized cyclopropenes. Electrophilic trapping of the cyclopropylmetal intermediates gave multifunctionalized cyclopropanes.

Saved in:
Bibliographic Details
Published inSynlett Vol. 26; no. 5; pp. 671 - 675
Main Authors Nakano, Takeo, Endo, Kohei, Ukaji, Yutaka
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 15.01.2015
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ALLYLZINCATION
CARBOZINCATION
catalysis
magnesium
ALPHA-AMINO-ACIDS
nucleophilic additions
organometallic reagents
IRON-CATALYZED CARBOMETALATION
alkenes
metalation
ASYMMETRIC CYCLOPROPANATION
CHEMISTRY
copper
STEREOSELECTIVE-SYNTHESIS
CONTAINING NATURAL-PRODUCTS
zinc
DERIVATIVES
Online AccessGet more information

Cover

More Information
Summary:A highly efficient method was developed for the copper(I)-catalyzed carbometalation of various nonfunctionalized and functionalized cyclopropenes. Electrophilic trapping of the cyclopropylmetal intermediates gave multifunctionalized cyclopropanes.
ISSN:0936-5214
1437-2096
DOI:10.1055/s-0034-1379959