Case report: Reversible splenial lesion syndrome caused by diquat poisoning

Diquat (DQ), chemically known as 1,1 ‘-ethylene-2,2’ -bipyridine, is a non-selective herbicide for leaf removal and drying. It has toxic effects on central nervous system cells, and toxic neurological lesions include axonal degeneration and pontine myelolysis. At the same time, DQ can also affect th...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in neurology Vol. 14
Main Authors Dai, Ping, Sun, Jin, Yu, Zhongkai, Zhang, Tongyue, Wen, Zixin, Jian, Tianzi, Guo, Lanlan, Genjiafu, Aerbusili, Kan, Baotian, Zhang, Binbin, Jian, Xiangdong
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 17.08.2023
Subjects
acute kidney injury
diquat
MRI
Neurology
reversible splenial lesion syndrome
toxic encephalopathy
Online AccessGet full text

Cover

More Information
Summary:Diquat (DQ), chemically known as 1,1 ‘-ethylene-2,2’ -bipyridine, is a non-selective herbicide for leaf removal and drying. It has toxic effects on central nervous system cells, and toxic neurological lesions include axonal degeneration and pontine myelolysis. At the same time, DQ can also affect the activity of dopaminergic nerve cells through oxidative stress, causing degeneration and reducing dopamine uptake. With the increasing application of DQ in agricultural production, the clinical reports of neurotoxicity caused by acute DQ poisoning are also increasing. At present, DQ rapid-phase-related toxic encephalopathy mainly involves the pons, midbrain, basal ganglia, thalamus and other brain regions. However, this case is unusual in that the lesion mainly involved the splenium of the corpus callosum. It is also the first time to be reported.
Bibliography:These authors have contributed equally to this work and share first authorship
Edited by: Fahim Mohamed, University of Peradeniya, Sri Lanka
Reviewed by: Yuto Uchida, Johns Hopkins Medicine, United States; Ronald Antulov, University Hospital of Southern Denmark, Denmark
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2023.1178272