Gastroretentive systems - a proposed strategy to modulate anthocyanin release and absorption for the management of diabetes

• Published in: Drug delivery Vol. 23; no. 6; pp. 1892 - 1901
• Main Authors: Celli, Giovana Bonat, Kalt, Wilhelmina, Brooks, Marianne Su-Ling
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 23.07.2016
• Subjects: Anthocyanins - administration & dosage; Anthocyanins - chemistry; Anthocyanins - pharmacokinetics; Bioavailability; Biological Availability; degenerative disease; delivery system; diabetes; Diabetes Mellitus, Type 2 - drug therapy; Diabetes Mellitus, Type 2 - metabolism; Drug Delivery Systems; Humans; stomach; Stomach - metabolism; delivery system; stomach; Bioavailability; diabetes; degenerative disease
• ISSN: 1071-7544; 1521-0464; 1521-0464
• DOI: 10.3109/10717544.2016.1143058

Several reports have indicated a positive correlation between the consumption of anthocyanins (ACN) and biomarkers relating to the improvement of type 2 diabetes (T2D). However, the results from in vitro studies often do not translate into clinical evidence. Potential causes of these discrepancies are experimental conditions that lack physiological relevancy; extensive degradation of these compounds in vivo due to changes in pH and metabolism; and a short residence time in the absorption window in relation to the absorption rate. Here, gastroretentive systems (GRS) are proposed as a strategy to overcome the limitations in ACN delivery and to reduce the existing bench-to-subject gap. This review summarizes recent literature on the use of ACN for the management and control of T2D, followed by GRS platforms to promote a sustained release of ACN for increased health benefits.