Antioedematogenic activity, acetylcholinesterase inhibition and antimicrobial properties of Jacaranda oxyphylla

• Published in: Natural product research Vol. 30; no. 17; pp. 1974 - 1979
• Main Authors: Pereira, V. V., Silva, R. R., dos Santos, M. H., Dias, D. F., Moreira, M. E. C., Takahashi, J. A.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.09.2016
• Subjects: AChE inhibition; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; anti-inflammatory; antibacterial activity; Bacillus cereus - drug effects; Bignoniaceae; Bignoniaceae - chemistry; Brazil; Cholinesterase Inhibitors - isolation & purification; Cholinesterase Inhibitors - pharmacology; Edema - drug therapy; Escherichia coli - drug effects; Inflammation - drug therapy; Jacaranda oxyphylla; Medicine, Traditional; Phytochemicals - isolation & purification; Phytochemicals - pharmacology; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Leaves - chemistry; Staphylococcus aureus - drug effects; Terpenes - isolation & purification; Terpenes - pharmacology; antibacterial activity; anti-inflammatory; Jacaranda oxyphylla; Bignoniaceae; AChE inhibition
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2015.1095744

Jacaranda oxyphylla Cham. (Bignoniaceae) is a shrub found in the Brazilian cerrado and used in folk medicine to treat microbial infections. The aim of this study was to carry out a phytochemical screening and evaluate antioedematogenic, antimicrobial and antiacetylcholinesterase properties of J. oxyphylla crude extracts. All extracts analysed showed presence of terpenoids, which are potentially active chemical substances. A high AChE inhibitory activity for hexane extract from leaves and for the extracts from twigs was found. Ethanol extract from leaves of J. oxyphylla showed activity against Gram-positive (Staphylococcus aureus and Bacillus cereus) and Gram-negative (Escherichia coli) bacteria. This extract was also effective in inhibiting the stages of inflammation evaluated. Biological investigation and phytochemical screening of J. oxyphylla extracts provided additional evidence of its traditional medicinal value.