MAP kinase signalling cascades and transcriptional regulation

• Published in: Gene Vol. 513; no. 1; pp. 1 - 13
• Main Authors: Yang, Shen-Hsi, Sharrocks, Andrew D., Whitmarsh, Alan J.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.01.2013
• Subjects: Animals; Cell Nucleus - metabolism; Chromatin; Chromatin - metabolism; gene expression; Gene Expression Regulation; genes; Humans; MAP Kinase Signaling System; MAP kinases; mechanism of action; Mice; mitogen-activated protein kinase; Phosphorylation; transcription (genetics); Transcription factors; Transcription, Genetic; C/EBPβ; MLK2; BRG1; IEGs; AP-1; ELK1; MPK1; bHLH; RACO-1; IFNγ; Bcd; RSC; Imp7; ATF1/2; RSK; PPARγ; ID-miRs; Hog1; ERK; HDAC; BAF60c/155; MSK1; Swi4; GATA4; NTS; Paf-1; CTR1; Rb; NLS; TAK1; miRNA; MKKK; JIP-1; MEF2; Xbp1; E-MAPs; Ste5/20; WSTF; EIN3; TRBP; MKK; FOSL1; TrkB; MKP; SOS; TAD; MnSOD; Pcr1; GRB2; TAB1; NuRD; Transcription factors; KSS1; JNK; ASH2L; p-TEFb; ATAC; MLL; HP-1; NFI; hnRNPK; ERK5; Cic; AML; NF-Y; FoxO; SPCH; ERα; MyoD; FOS; MAPK; ER; ZAP70; MEK; CREB1; MPK3/6; Chromatin; Phosphorylation; RNF4; BMK1; Mxi2; SBF; RBA-1; MAP kinases; STAT5; MEKK; BRD4; MBD3; KAP-1; PEA3; EGF; MOF; PARP-1; KLF2; MP1; ETV3/4; ChIP-seq; Nup50/153/214
• ISSN: 0378-1119; 1879-0038
• DOI: 10.1016/j.gene.2012.10.033

The MAP kinase (MAPK) signalling pathways play fundamental roles in a wide range of cellular processes and are often deregulated in disease states. One major mode of action for these pathways is in controlling gene expression, in particular through regulating transcription. In this review, we discuss recent significant advances in this area. In particular we focus on the mechanisms by which MAPKs are targeted to the nucleus and chromatin, and once there, how they impact on chromatin structure and subsequent gene regulation. We also discuss how systems biology approaches have contributed to our understanding of MAPK signaling networks, and also how the MAPK pathways intersect with other regulatory pathways in the nucleus. Finally, we summarise progress in studying the physiological functions of key MAPK transcriptional targets. ► Targeting mechanisms of MAPKs to the nucleus and chromatin ► MAPKs in controlling chromatin structure ► Systems analysis of nuclear MAPK signaling networks ► Complexities of MAPK signaling in the nucleus ► Physiological functions of MAPK transcriptional targets