A strategic study towards constructing the nine-membered azonane ring system of palhinine A via an azidoketol fragmentation reaction
A proposed strategy for constructing the nine-membered azonane ring system embedded in the isotwistane framework of palhinine A has been preliminarily studied on the basis of an azidoketol fragmentation reaction together with a SmI2-mediated pinacol coupling. Albeit negative results for building the...
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Published in | Science China. Chemistry Vol. 59; no. 9; pp. 1188 - 1196 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Beijing
Science China Press
01.09.2016
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | A proposed strategy for constructing the nine-membered azonane ring system embedded in the isotwistane framework of palhinine A has been preliminarily studied on the basis of an azidoketol fragmentation reaction together with a SmI2-mediated pinacol coupling. Albeit negative results for building the azonane ring scaffold via a tertiary azidoketol fragmentation, the present exploration strategically provided an endeavor to probe the synthetically challenging issue in the synthetic study of palhinine A. |
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Bibliography: | alkaloids, azonane ring, isotwistane, natural product synthesis, pinacol coupling, fragmentation reaction A proposed strategy for constructing the nine-membered azonane ring system embedded in the isotwistane framework of palhinine A has been preliminarily studied on the basis of an azidoketol fragmentation reaction together with a SmI2-mediated pinacol coupling. Albeit negative results for building the azonane ring scaffold via a tertiary azidoketol fragmentation, the present exploration strategically provided an endeavor to probe the synthetically challenging issue in the synthetic study of palhinine A. 11-5839/O6 |
ISSN: | 1674-7291 1869-1870 |
DOI: | 10.1007/s11426-016-0059-7 |