Large cerebral artery involvement in CADASIL

The authors evaluated the involvement of large cerebral artery in 13 patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with angiography (12 MR and one conventional). Five patients (38%) showed stenosis: at the middle cerebral artery in...

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Bibliographic Details
Published inNeurology Vol. 65; no. 8; p. 1322
Main Authors Choi, Eun J, Choi, Choong G, Kim, Jong S
Format Journal Article
LanguageEnglish
Published United States 25.10.2005
Subjects
Adult
Aged
Brain - blood supply
Brain - diagnostic imaging
Brain - pathology
CADASIL - diagnosis
CADASIL - physiopathology
Carotid Stenosis - diagnosis
Carotid Stenosis - physiopathology
Cerebral Angiography
Cerebral Arteries - diagnostic imaging
Cerebral Arteries - pathology
Cerebral Arteries - physiopathology
Disease Progression
Female
Humans
Infarction, Middle Cerebral Artery - diagnosis
Infarction, Middle Cerebral Artery - physiopathology
Magnetic Resonance Angiography
Male
Middle Aged
Predictive Value of Tests
Prognosis
Risk Factors
Vertebrobasilar Insufficiency - diagnosis
Vertebrobasilar Insufficiency - physiopathology
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Summary:The authors evaluated the involvement of large cerebral artery in 13 patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with angiography (12 MR and one conventional). Five patients (38%) showed stenosis: at the middle cerebral artery in three, vertebral artery in one, and the internal carotid artery in one. The stenosis persisted on follow-up angiogram in two patients. There were no differences in risk factors between patients with angiographic abnormality and those without, suggesting occasional involvement of large vessels in CADASIL.
ISSN:1526-632X
DOI:10.1212/01.wnl.0000180965.79209.50