Matrix metalloproteinases: they're not just for matrix anymore

The matrix metalloproteinases (MMPs) have been viewed as bulldozers, destroying the extracellular matrix to permit normal remodeling and contribute to pathological tissue destruction and tumor cell invasion. More recently, the identification of specific matrix and non-matrix substrates for MMPs and...

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Bibliographic Details
Published inCurrent Opinion in Cell Biology Vol. 13; no. 5; pp. 534 - 540
Main Authors McCawley, Lisa J, Matrisian, Lynn M
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2001
Subjects
angiogenesis, tumor progression
Animals
Apoptosis
Cell Communication
Cell Division
Cell Movement
cell proliferation
extracellular matrix
Extracellular Matrix - metabolism
Extracellular Matrix Proteins - metabolism
immune defense
invasion
matrix metalloproteinase
Matrix Metalloproteinases - physiology
metastasis
Neoplasm Invasiveness
Neoplasm Metastasis
Immunology
cell proliferation
invasion
metastasis
immune defense
angiogenesis, tumor progression
Cell biology
matrix metalloproteinase
apoptosis
Cancer Biology
Molecular Medicine
extracellular matrix
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Summary:The matrix metalloproteinases (MMPs) have been viewed as bulldozers, destroying the extracellular matrix to permit normal remodeling and contribute to pathological tissue destruction and tumor cell invasion. More recently, the identification of specific matrix and non-matrix substrates for MMPs and the elucidation of the biological consequence of cleavage indicates that perhaps MMPs should be viewed more as pruning shears, playing sophisticated roles in modulating normal cellular behavior, cell–cell communication and tumor progression.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0955-0674
1879-0410
DOI:10.1016/S0955-0674(00)00248-9