The effect of pretreatment with hydroalcoholic extract of Alpinia officinarum rhizome on seizure severity and memory impairment in pentylenetetrazol-induced kindling model of seizure in rat

• Published in: AIMS neuroscience Vol. 6; no. 3; pp. 128 - 145
• Main Authors: Solati, Kamal, Rabiei, Zahra, Asgharzade, Samira, Amini-Khoei, Hossein, Hassanpour, Ali, Abbasiyan, Zahra, Anjomshoa, Maryam, Rafieian-Kopaei, Mahmoud
• Format: Journal Article
• Language: English
• Published: United States AIMS Press 01.01.2019
• Subjects: Alpinia officinarum; memory; pentylentetrazol; seizure; pentylentetrazol; Alpinia officinarum; memory; seizure
• ISSN: 2373-7972; 2373-8006; 2373-7972
• DOI: 10.3934/Neuroscience.2019.3.128

The aim of present study is to investigate pretreatment with hydroalcoholic extract of rhizome on the severity of epilepsy and memory impairment in rat. In this experimental study, rats were randomly assigned to seven groups. Control group and negative control group were intraperitoneally injected with normal saline and PTZ, respectively, for 10 days. The intervention groups received . extract at different doses (50, 100 and 150 mg/kg) 30 minutes before PTZ injection. . extract treatment in rats with PTZ-induced kindling exerted significant increase in seizure latency and significant decrease in the frequency of total body seizure, frequent spinning, and jumping. Flumazenil significantly inhibited the antiepileptic effects of A. extract in the rat receiving the extract at 150 mg/kg. . extract can inhibit PTZ-induced seizure and memory impairment, and therefore can be considered as a potent agent which warranted further research to clarify its effects.