Mass spectrometric analysis of acid-assisted photochemical release of the trimethyl lock system on the monolayers on gold

We report the acid-assisted photolysis of the trimethyl lock system which has long been harnessed for a variety of applications such as drug delivery, cellular imaging, enzyme activity assays, and surface patterning. By mass spectrometric analysis, we found that photoinduced intramolecular cyclizati...

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Bibliographic Details
Published inRSC advances Vol. 1; no. 3; pp. 17914 - 17917
Main Authors Yu, Geunhyeok, Yeo, Woon-Seok
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 11.05.2020
The Royal Society of Chemistry
Subjects
Chemistry
Drug delivery systems
Enzyme activity
Monolayers
Photolysis
Self-assembled monolayers
Self-assembly
Spectrometry
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Summary:We report the acid-assisted photolysis of the trimethyl lock system which has long been harnessed for a variety of applications such as drug delivery, cellular imaging, enzyme activity assays, and surface patterning. By mass spectrometric analysis, we found that photoinduced intramolecular cyclization and the ensuing release of the pendant groups of the trimethyl lock on the self-assembled monolayers proceeded cleanly in the presence of HCl, to give a high yield. The acid-assisted photolysis of the trimethyl lock on the surface was characterized by mass spectrometry.
Bibliography:10.1039/d0ra02110e
Electronic supplementary information (ESI) available: Experimental section and additional figures. See DOI
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ISSN:2046-2069
2046-2069
DOI:10.1039/d0ra02110e