Adiponectin stimulates IL-8 production by rheumatoid synovial fibroblasts

• Published in: Biochemical and biophysical research communications Vol. 378; no. 2; pp. 218 - 223
• Main Authors: Kitahara, Kanako, Kusunoki, Natsuko, Kakiuchi, Terutaka, Suguro, Toru, Kawai, Shinichi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.01.2009
• Subjects: 60 APPLIED LIFE SCIENCES; Adiponectin; Adiponectin - antagonists & inhibitors; Adiponectin - immunology; Adiponectin - pharmacology; ANTIBODIES; Arthritis, Rheumatoid - immunology; Cells, Cultured; Chemokine; Chemotaxis - drug effects; FIBROBLASTS; Fibroblasts - drug effects; Fibroblasts - immunology; GENES; Humans; INFLAMMATION; INHIBITION; Interleukin-8 - biosynthesis; LEPTIN; Neutrophils - drug effects; Neutrophils - immunology; PATHOGENESIS; Protein Kinase Inhibitors - pharmacology; Receptors, Adiponectin - biosynthesis; RHEUMATIC DISEASES; Rheumatoid arthritis; Signal Transduction; Synovial Fluid - drug effects; Synovial Fluid - immunology; Chemokine; Inflammation; Rheumatoid arthritis; Adiponectin
• ISSN: 0006-291X; 1090-2104
• DOI: 10.1016/j.bbrc.2008.11.017

The adipokines are linked not only to metabolic regulation, but also to immune responses. Adiponectin, but not leptin or resistin induced interleukin-8 production from rheumatoid synovial fibroblasts (RSF). The culture supernatant of RSF treated with adiponectin induced chemotaxis, although adiponectin itself had no such effect. Addition of antibody against adiponectin, and inhibition of adiponectin receptor gene decreased adiponectin-induced IL-8 production. Nuclear translocation of nuclear factor-kappa B was increased by adiponectin. The induction of interleukin-8 was inhibited by mitogen-activated protein kinase inhibitors. These findings suggest that adiponectin contributes to the pathogenesis of rheumatoid arthritis.