Effects of a carbamate, BPMC, on the central cholinergic functions and behavior of mice

O-sec-butylphenyl methylcarbamate (BPMC), an anticholinesterase carbamate, was injected once (100mg/kg, s.c.) or repeatedly (50mg/kg/day for 10 days) into mice. Animals were examined for their behavior and for parameters of cholinergic activity in the forebrain. Mice that received only a single inje...

Full description

Saved in:
Bibliographic Details
Published inJapanese journal of veterinary science Vol. 51; no. 4; pp. 789 - 795
Main Authors Kobayashi, H. (Iwate Univ., Morioka (Japan). Faculty of Agriculture), Yuyama, A, Shioya, K, Sato, K
Format Journal Article
LanguageEnglish
Japanese
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.08.1989
Subjects
ACETILCOLINA
ACETILCOLINESTERASA
ACETYLCHOLINE
Acetylcholine - metabolism
ACETYLCHOLINESTERASE
Animals
behavior
Behavior, Animal - drug effects
BEHAVIOUR
BPMC
Brain - metabolism
carbamate
Carbamates - pharmacology
CHOLINE
Choline - metabolism
cholinergic activity
COLINA
COMPORTAMIENTO
COMPORTEMENT
ENSAYO
Female
INJECTION
INYECCION
MICE
Mice, Inbred ICR
RATON
SOURIS
TESTAGE
TESTING
Online AccessGet full text

Cover

More Information
Summary:O-sec-butylphenyl methylcarbamate (BPMC), an anticholinesterase carbamate, was injected once (100mg/kg, s.c.) or repeatedly (50mg/kg/day for 10 days) into mice. Animals were examined for their behavior and for parameters of cholinergic activity in the forebrain. Mice that received only a single injection exhibited reduced ambulation, hypothermia, and impairment of rotarod performance for up to 3 hr after a single injection. BPMC increased levels of acetylcholine (ACh) in the forebrain for up to 6 hr, and decreased acetylcholinesterase (AChE) activity for up to 24 hr. Both high-affinity choline uptake (HACU) and binding of [3H] quinuclidinyl benzilate (QNB) were reduced 20 min after a single injection without any effect on choline acetyltransferase (ChAT) activity. In behavioral tests conducted 10 min prior to the daily injections, rotarod performance and ambulation were slightly impaired for a few days before and after cessation of injection. Repeated treatment decreased HACU and binding of [3H] QNB for 24 hr after the final injection without any changes in levels of ACh content, AChE activity and ChAT activity. BPMC may reversibly impair cholinergic functions through effects not only on AChE activity but also on HACU and binding of [3H] QNB.
Bibliography:L70
9202174
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-5295
1881-1442
DOI:10.1292/jvms1939.51.789